Italy's highest court has ordered American Amanda Knox and her former boyfriend Raffaele Sollecito to face a retrial for the 2007 killing of British student Meredith Kercher.
The Court of Cassation overturned the pair's acquittal and ordered an appeals court in Florence re-hear the high-profile case that led to Knox and Sollecito spending four years in jail before being freed in October 2011. A lack of compelling DNA evidence prompted the case to be overturned.
On Monday, Knox was reported by her lawyer to be "very anxious" about the prospect of a retrial.
Immediately following the announcement, Knox told the Associated Press that it was "painful" to have the acquittal overturned but that she was "confident" about the truth.
Kercher's body was found in November 2007 in her bedroom of the house she shared with Knox and other roommates in Perugia, an Italian university town where the two women were exchange students. Her throat had been slashed.
Prosecutors argued that Kercher, from south London, was murdered as a result of a sex game that went amiss.
An Ivory Coast man, Rudy Guede, was convicted of the slaying in a separate proceeding and is serving a 16-year sentence.
Legal experts will now be looking to gauge the likelihood of Knox, who lives in Seattle, being extradited to Italy to stand trial.
No time table for the proceedings has been released.
"Start all over again in trial for Amanda and Sollecito," ran a headline for Correiere della Sera, Italy's newspaper of record.
Contributing: Associated Press
Kim Hjelmgaard, USA TODAY